Upper Bound Analysis and Routing in Optical Benes Networks

Multistage Interconnection Networks (MIN) are popular in switching and communication applications. It has been used in telecommunication and parallel computing systems for many years. The new challenge facing optical MIN is crosstalk, which is caused by coupling two signals within a switching element. Crosstalk is not too big an issue in the Electrical Domain, but due to the stringent Bit Error Rate (BER) constraint, it is a big major concern in the Optical Domain. In this research dissertation, we will study the blocking probability in the optical network and we will study the deterministic conditions for strictly non-blocking Vertical Stacked Optical Benes Networks (VSOBN) with and without worst-case scenarios. We will establish the upper bound on blocking probability of Vertical Stacked Optical Benes Networks with respect to the number of planes used when the non-blocking requirement is not met. We will then study routing in WDM Benes networks and propose a new routing algorithm so that the number of wavelengths can be reduced. Since routing in WDM optical network is an NP-hard problem, many heuristic algorithms are designed by many researchers to perform this routing. We will also develop a genetic algorithm, simulated annealing algorithm and ant colony technique and apply these AI algorithms to route the connections in WDM Benes network

Thyroid function and associated mood changes after COVID-19 vaccines in patients with Hashimoto thyroiditis

ContextSevere acute respiratory syndrome-coronavirus 2 (COVID-19) vaccines may incur changes in thyroid functions followed by mood changes, and patients with Hashimoto thyroiditis (HT) were suggested to bear a higher risk.ObjectivesWe primarily aim to find whether COVID-19 vaccination could induce potential subsequent thyroid function and mood changes. The secondary aim was to find inflammatory biomarkers associated with risk.MethodsThe retrospective, multi-center study recruited patients with HT receiving COVID-19–inactivated vaccines. C-reactive proteins (CRPs), thyroid-stimulating hormones (TSHs), and mood changes were studied before and after vaccination during a follow-up of a 6-month period. Independent association was investigated between incidence of mood state, thyroid functions, and inflammatory markers. Propensity score–matched comparisons between the vaccine and control groups were carried out to investigate the difference.ResultsFinal analysis included 2,765 patients with HT in the vaccine group and 1,288 patients in the control group. In the matched analysis, TSH increase and mood change incidence were both significantly higher in the vaccine group (11.9% versus 6.1% for TSH increase and 12.7% versus 8.4% for mood change incidence). An increase in CRP was associated with mood change (p< 0.01 by the Kaplan–Meier method) and severity (r = 0.75) after vaccination. Baseline CRP, TSH, and antibodies of thyroid peroxidase (anti-TPO) were found to predict incidence of mood changes.ConclusionCOVID-19 vaccination seemed to induce increased levels and incidence of TSH surge followed by mood changes in patients with HT. Higher levels of pre-vaccine serum TSH, CRP, and anti-TPO values were associated with higher incidence in the early post-vaccine phase